Thank you for your interest in a career at Senti Biosciences. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. We are passionate about designing gene circuits to improve the “intelligence” of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines are unable to address.
At Senti, we find purpose and meaning knowing that our efforts have the potential to improve the lives of patients and their families with more effective and safer treatment options. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.
Summary:
The successful candidate will have prior experience with cell therapy early- and late-stage development. The individual will be responsible for planning and executing pivotal phase development activities of Senti’s lead Allo-CAR NK program, including identification of critical process parameters, process characterization, scale up, and technical transfer to our CMO. The deliverables will involve selection and development of processes and technology for all unit ops including NK cell enrichment and activation, transduction, expansion, formulation, fill, cryopreservation and collaboration with the analytical development group to define suitable in-process samples for testing and process monitoring. This position will also support development and refinement of a robust donor screening program for NK cell sourcing.
Responsibilities:
Independently design, plan, and execute process development studies to enable scale-up processes, characterization, process improvements, process comparability and process robustness
Support evaluation of alternate technologies for cell therapy processing for cell enrichment, transduction, expansion, and fill finish
Position will be onsite with substantial lab time initially and collaborate with the process development team.
Pivotal phase process readiness of CT unit operations with a focus on Drug Product formulation/filling/cryopreservation that aligns with overall program strategy
Write and review technical documentation including process development reports, IND filings, change controls, batch records, tech transfer plans, process comparability protocols
Participate and influence a cross-functional development team to advance program development activities
Support pipeline project in collaboration with R&D team and develop early-stage and phase-appropriate processes for new programs.
Lead risk assessments, troubleshooting, and tech transfers as necessary
Qualifications:
Advanced scientific degree (i.e. PhD) in in Biochemical Engineering, Chemical Engineering, Biomedical Engineering, Biotechnology and 6 years of related experience OR
Master’s Degree in Biochemical Engineering, Chemical Engineering, Biomedical Engineering or Biotechnology and 8 years of related experience OR
BS/BA in Biology, Chemistry, or Engineering and 10 years of related experience
Salary and Benefits:
Compensation for this role includes base salary, annual target bonus and equity
The base salary range for this role is $175,000- $208,000. Starting pay is determined by multiple job-related factors including a candidate’s skills, education and experience level, benchmark, and internal parity
Significant growth opportunity as the company expands
Empathetic, supportive and collaborative colleagues and work environments
Senti Bio is a publicly traded (Nasdaq: SNTI) gene circuit company headquartered in South San Francisco. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases using novel and unprecedented approaches.
We are committed to an inclusive and diverse Senti Bio. We believe that different perspectives lead to better ideas, and better ideas allow us to better understand the needs and interests of our diverse Senti Team. We welcome people of different backgrounds, experiences, abilities and perspectives and are an equal opportunity employer.